Reduction of blood glucose due to the increase of intracellular transport, absorption and assimilation tissue enhancement, stimulation of lipogenesis, glikogenogeneza, speed reduction glucose production by the liver, and others.
The duration of action of insulin formulations is mainly due to absorption rate, which depends on several factors (e.g., dose , method and site of administration), and therefore the action of equipoise side effects insulin profile is subject to significant fluctuations, like different people, and at one and the same person. profile action after subcutaneous injection (approximate figures): onset of action after 1.5 hours, maximum effect – in the range between 3 and 10 hours duration – 24 hours.
The completeness of the suction and the beginning of the insulin effect is dependent on the injection site (abdomen, thigh, buttocks), the dose (amount of injected insulin), insulin concentration in the formulation, etc. distributed in the body unevenly.; It does not cross the placental barrier and into breast milk. It destroyed insulinase mainly in the liver and kidneys. Excreted by the kidneys (30-80%).
- Diabetes mellitus type 1
- Diabetes mellitus type 2: stage of resistance equipoise side effects to oral hypoglycemic agents, partial resistance to these drugs (in combination therapy), intercurrent illness
- Increased individual’s sensitivity to insulin, or any of the components
Dosing and Administration
Gensulin H is designed for subcutaneous administration. Dose determined by the physician individually in each case, on the basis of blood glucose levels. On average, the daily dose ranges from 0.5 to 1 IU / kg body weight (depending on the individual patient and the level of blood glucose).
The temperature equipoise side effects of insulin must comply room.
Gensulin H is usually administered subcutaneously in the thigh. Injections can be done as well in the abdominal wall, the buttocks or the area of the deltoid muscles of the shoulder.
It is necessary to change the injection sites within the anatomical region to prevent the development of lipodystrophy.
Gensulin H can be driven both independently and in combination with short-acting insulin (Gensulin P) .
Side effects caused by the effect on carbohydrate metabolism : hypoglycemic state (pale skin, increased sweating, palpitations, tremor, hunger, excitement, paresthesia in the mouth, headache). Severe hypoglycemia may lead to the development of hypoglycemic coma. Allergic reactions : seldom – skin rash, angioedema, rarely – anaphylactic shock. Local reactions : redness, swelling and itching at the injection site, with prolonged use – lipodystrophy at the injection site. Other – swelling , transient disturbances of refraction (usually at the beginning of therapy).
In case of overdose may develop hypoglycemia. Treatment : mild hypoglycemia, the patient can remove himself, taking into sugar or carbohydrate-rich foods. Therefore, patients with diabetes should always carry sugar, sweets, biscuits or sugary fruit juice. In severe cases, loss of consciousness of the patient, intravenous 40% dextrose; intramuscularly, subcutaneously, intravenously – glucagon. After regaining consciousness of the patient is recommended to take food rich in carbohydrates, to prevent recurrence of hypoglycemia.
The interaction with other drugs
There are a number of drugs that affect the demand for insulin.
Hypoglycemic effect of insulin enhance oral hypoglycemic agents, monoamine oxidase inhibitors, angiotensin converting enzyme inhibitors, carbonic anhydrase inhibitors, selective beta-blockers.bromocriptine, octreotide, sulfonamides, anabolic steroids, tetracyclines, clofibrate, ketoconazole, mebendazole, pyridoxine, theophylline, cyclophosphamide, fenfluramine, lithium, drugs containing equipoise side effects ethanol.Hypoglycemic effect of insulin impaired oral contraceptives, steroids, thyroid hormones, thiazide diuretics, heparin, tricyclic antidepressants, sympathomimetics, danazol, clonidine, calcium channel blockers, diazoxide, morphine, phenytoin, nicotine. Under the influence of reserpine and salicylates may as a weakening or strengthening of the drug.
Do not use Gensulin H if after shaking the suspension becomes uniformly white and cloudy.
Against the background of insulin therapy requires constant monitoring of blood glucose levels. The causes of hypoglycemia than insulin overdose can be: the replacement of the drug, skipping meals, vomiting, diarrhea, increased physical activity, disease, reducing the need for insulin (human liver and kidneys, hypofunction of the adrenal cortex, pituitary or thyroid gland), change the injection site, as well as interaction with other drugs.
Incorrect dosage or interruption of insulin delivery, particularly in patients with type 1 diabetes, may lead to hyperglycaemia. Usually the first symptoms of hyperglycaemia develop gradually over several hours or days. These include the emergence of thirst, frequent urination, nausea, vomiting, dizziness, redness and dryness of the skin, dry mouth, loss of appetite, the smell of acetone in exhaled air. If left untreated, hyperglycemia in diabetes mellitus type 1 can lead to life-threatening diabetic ketoacidosis. The dose of insulin should be corrected with thyroid disorders, Addison’s disease, hypopituitarism, violations of liver and kidney function and diabetes mellitus in persons over 65 years.
The correction dose of insulin may also be required if the patient increases the intensity of physical activity or change the habitual diet.
Comorbidities especially infections and conditions accompanied by fever, increase insulin requirements.
The transition from one type of insulin in the other should be under the control of blood glucose levels.
The drug reduces tolerance to alcohol.
in connection with the possibility of precipitation of some equipoise side effects catheters are not recommended drug in insulin pumps.
Effects on ability to drive vehicles and management mechanisms
In connection with the primary purpose of insulin, changing its appearance or the presence of significant physical or mental stress, may reduce the ability to drive a car or to the management of a variety of mechanisms, as well as studies in other potentially hazardous activities that require attention and speed of mental and motor responses.
Injection 100 IU / ml in 10 ml glass vials and 3 ml cartridges. 1 bottle with instruction on the medical application is placed in a cardboard box. 5 placed in blister cartridges, and together with instructions for use placed in a cardboard box.
at temperatures between 2 and 8 ° C. Do not freeze. After opening the package, the drug store at temperatures above 25 ° C for 28 days in a dark place. Keep out of the reach of children.
2 years. Do not use beyond the expiration date. Buy musclelabsusa steroids online