Interferon alfa-2b has antiviral, immunomodulatory, antiproliferative and antibacterial act. The antiviral effect is mediated by activation of several intracellular enzymes that inhibit viral replication. Immunomodulatory equipoise only cycle effects manifested, first of all, increasing cell-mediated immune reactions, which increases the efficiency of the immune response against viruses, intracellular parasites and cells which have undergone a neoplastic transformation. This is achieved by activation of CD8 + killer T cells, NK-cells (natural killer cells), enhancing differentiation of B lymphocytes and the production of antibodies to, activation of the monocyte-macrophage system and phagocytosis as well as increasing the expression of molecules of the major histocompatibility complex I type, which increases the likelihood detection of infected cells by cells of the immune system. Activation under the influence of leukocyte interferon contained in all mucosal layers ensures their active participation in the elimination of lesions; In addition, due to the effect of interferon is achieved by restoring the production of secretory immunoglobulin A. The antibacterial effect is mediated by the immune system, strengthens under the influence of interferon.
Taurine helps to normalize metabolic processes and tissue regeneration, has a membrane and immunomodulatory effects. As a powerful antioxidant, taurine interacts directly with the reactive oxygen species, the excessive accumulation of which contributes to the development of pathological processes. Taurine helps to preserve the biological activity of interferon, increasing the therapeutic effect of the drug.
Benzocaine (benzocaine) is a local anesthetic. Reduces cell membrane permeability to sodium ions displace calcium ions from the receptors located on the inner surface of the membrane, blocking the conduction of nerve impulses. It prevents the appearance of pain impulses in the sensory nerve endings and their implementation on the nerve fibers. It has only a local effect, without being absorbed into the systemic circulation.
When rectal administration of the drug have a high bioavailability (80%) of interferon, in connection with what is achieved both local and pronounced systemic immunomodulatory effects; in intravaginal application, due to the high concentration in the infected site and fixing the mucosal cells achieved a pronounced local antiviral, antiproliferative and antibacterial effects, and the systemic effect due to low vaginal mucosa small suction capacity. The maximum concentration of interferon in serum is reached after 5 hours after drug administration. The main route of excretion alpha-inter-Feron is renal catabolism.The half-life is 12 hours, which necessitates the use of the drug 2 times a day.
Indications for use
in the complex therapy in equipoise only cycle infectious and inflammatory diseases of the urogenital tract in adults: genital herpes, chlamydia, ureaplasmosis, mycoplasmosis, recurrent vaginal candidiasis, bacterial vaginosis, trichomoniasis, human papillomavirus infection, bacterial vaginosis, cervical erosion, cervicitis, vulvovaginitis, Bartholinitis, adnexitis, prostatitis, urethritis, balanitis, balanoposthitis,
in the complex therapy of acute bronchitis in adults.
Dosing and Administration
1. Infectious and inflammatory diseases of the urogenital tract of women. 1 suppository (250 or 500 000 IU 000 IU or 1,000,000 IU depending on the severity of the disease), rectally or vaginally (depending on the nature of the disease), 2 times a day every day for 10 days. In protracted forms of 3 times a week, every other day 1 suppository for 1-3 months.
In marked infectious inflammation of the vagina is possible to use 1 suppository 500 000 IU intravaginally in the morning and 1 suppository 1 million IU rectally for the night at the same time with the introduction of vaginal suppository containing antibacterial / antifungal agents.
use 1 suppository 250 000 IU vaginal 2 times a day every day for 10 days for the normalization of the local immunity in the treatment of infectious and inflammatory diseases urinogenous tal-tract in women during pregnancy 13-40 weeks .
2. Infectious and inflammatory diseases of the urogenital tract of men.
Rectal 1 suppository (500 or 000 IU IU 1,000,000 depending on the severity of the disease), 2 times a day for 10 days.
3. In the combined therapy of acute bronchitis in adults.
In one suppository (1,000,000 I.U.) 2 rectally twice a day for 5 days.
The product is well tolerated by patients. Chance of local allergic reactions (burning sensation in the vagina). These phenomena are reversible and disappears within 72 hours after cessation of administration.Continued treatment may, after consultation with the doctor. There may be problems arising from the application of all types of interferon alfa-2b, such as chills, fever, fatigue, loss of appetite, muscle and headaches, joint pain, sweating, and leuko- and thrombocytopenia, but most often they are equipoise only cycle found in excess the daily dose over 10 million IU. To date, no serious adverse events were observed.
As with any other alpha-2b interferon drug, in the case of temperature increase after the introduction of possible single dose of paracetamol at a dose of 500-1000 mg.
Individual intolerance to interferon and other substances in the preparation.
aggravation of allergic and autoimmune diseases.
Use during pregnancy and lactation
is shown application for the normalization of the local immunity in pregnancy 13-40 weeks in the complex therapy of genital herpes, chlamydia, ureaplasma, mycoplasma, cytomegalovirus infection, human papillomavirus infection, bacterial vaginosis if there is itching, discomfort and pain in the area of the lower parts of the equipoise only cycle urogenital tract.
Clinical studies have proven the use of intravaginal drug safety Genferon ® 250 000 IU during pregnancy 13-40 weeks. The safety of the drug in the I trimester of pregnancy has not been studied.
The interaction with other drugs
Genferon ® is most effective in combination with drugs (including antibiotics and other antimicrobial agents) used for the treatment of urogenital diseases. Non-narcotic analgesics and anticholinesterase drugs enhance the effect of benzocaine. Benzocaine reduces the antibacterial activity of sulfonamides.
cases of drug overdose Genferon ® have been reported. When one-time random number suppositories administered more than prescribed physician should suspend further administering for 24 hours, after which the treatment can be resumed at a prescribed pattern.
To prevent urogenital reinfection encouraged to consider the simultaneous treatment of sexual partners.
Allowed to use the drug during menstruation.
The drug Genferon ® does not affect the performance of potentially hazardous activities that require attention and fast reactions (management of vehicles, machinery, and so on. P.). steroids for building muscle oral steroids for sale where can i buy steroid cream