Action hypertonic saline short-lived due to the elimination of sodium and equipoise for sale chloride ions from the vessel. Dextran 40 during 3-4 hours keeping the liquid in the bloodstream, maintains blood volume, providing thus hemodynamic effects. The maximum effect on blood volume is the total effect of hypertonic saline and dextran 40. The drug has volemic action within 150-200% of the injected volume, which is maintained for 30-60 minutes. Infusion of 250 ml Gemostabila gives an increase intravascular volume to 1000 ml for 5 minutes.
The combination of sodium chloride and dextran 40 does not alter the pharmacokinetic properties of each component. The sodium content in the blood plasma after administration Gemostabila increased to 9.12 mmol / l, returning to normal in less than 4 h. The half-life Dextran 40 – 3-4 hours, excreted by the kidneys in the urine in unchanged form.
Indications for use:
Designed to fill the initial circulating blood equipoise for sale volume deficiency for the prevention and treatment of hypovolemia and shock with hypotension in acute blood loss, trauma, injuries, surgery, burns, infectious diseases.
Known hypersensitivity / allergic to the drug or its components, late pregnancy and lactation, severe cardio-pulmonary insufficiency; renal failure, hyperhydration. Childhood.
Dosage and administration. Gemostabil administered as an intravenous infusion in the peripheral or central vein. Introduction is performed once, a bolus dose of 250 ml, during 2-4 minutes. 250 ml of the product Gemostabil is the optimal dose. The increase in blood volume and hemodynamic stabilization reduces the risk of irreversible pathological reactions of an organism in response to acute hypovolemia.After transfusion preparation Gemostabil infusion therapy continue with crystalloid and colloid solutions, blood products in required quantities. Preferably, following the introduction of Gemostabila use isotonic solutions.
Symptoms of overdose equipoise for sale are not established.
With care prescribe a drug for severe disorders of blood coagulation (except for life-threatening conditions), dehydration. Since Gemostabil for a short time increases the fluid volume should pay attention to patients with heart failure. In patients with diabetes with severe hyperglycemia and hyperosmolarity, Gemostabil should be used with caution. The treatment must control the ionic composition of blood serum, the fluid balance and renal function. With the introduction of the drug in peripheral veins may cause a burning sensation and pain in the limbs along the vein, which carried out the infusion of the drug
For some individuals may equipoise for sale experience intolerance reactions in exceptional cases, allergic reactions of various types up to anaphylactic / anaphylactoid events. In this case, you should immediately discontinue administration of the drug and make the necessary urgent measures.
Interaction with other medicinal products and drugs have been identified.
Infusion solution 100, 250, 500 ml plastic containers in infusion solutions for single use.
In a dry place at a temperature of 10 to 30 ° C is allowed to freeze during transport. Keep out of the reach of children.