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Gentamicin is an antibiotic of the aminoglycoside group. Its mechanism of action is in violation of the synthesis of bacterial proteins by binding to the 30S-subunit of bacterial ribosomes. Thus there is inappropriate formation of proteins with amino acid sequences.Gentamicin has a bactericidal effect in vitro against the following strains of bacteria: Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus buy equipoise pneumoniae, Enterobacter aerogenes, Escherichia coli, Haemophilus influenza, Klebsiella pneumoniae, Neisseria gonorrhoeae, Pseudomonas aeruginosa, Serratia marcescens. Tobramitsinrezistentnye microorganisms are also resistant to gentamicin action (cross-resistance).  Absorption of gentamicin when applied topically significantly.

 

Indications :
Bacterial infections of the eye caused by sensitive microflora – blepharitis, blefarokonyunktivit, dacryocystitis, conjunctivitis, keratitis, keratoconjunctivitis, meybomit, prevention of post-operative and post-traumatic infection.

Contraindications :

  • hypersensitivity to any component of the formulation or aminoglycoside antibiotic;
  • Children under 1 year;
  • pregnancy;
  • lactation (breastfeeding);
  • severe renal impairment;
  • neuritis of the auditory nerve;
  • myasthenia gravis.

Precautions
Long-term topical application of the drug may lead to secondary bacterial and fungal infections.
In the case of protracted bacterial eye infection topical treatment should be supplemented with the use of antibiotics for systemic effects.

Pregnancy and lactation
During pregnancy, the drug is contraindicated.
In the appointment during lactation should stop breastfeeding.

Dosage and administration:
Adults and children older than 1 year
When infection of the eyes of average weight for 1 – 2 drops every 4 hours in the lower conjunctival sac; in severe lesions of 1-2 drops every hour. The duration of no more than 14 days.

Side effects
during treatment may buy equipoise appear: watery eyes, eye redness, pain and burning sensation in the eyes, photophobia. These symptoms can persist for several minutes after the installation of the preparation.
Long-term use in the case of high sensitivity to the drug in a few cases leads to the appearance of local allergies, thrombocytopenic purpura, hallucinations.
If any of these instructions adverse effects are exacerbated or you notice any other side effects not mentioned in the instructions, inform your doctor.

Overdose
No data concerning overdose in the local application of gentamicin.

The interaction with other drugs
during the application of gentamicin sulfate in the form of eye drops is set not clinically significant drug interactions, with the exception of cross-resistance to tobramycin.

Cautions
Taking into account the content of the formulation benzalkonium chloride, soft contact lenses should be removed prior to instillation and install them no earlier than 15 minutes after instillation. Benzalkonium chloride may cause eye irritation and discolour contact lenses.
The effect on driving and perform potentially hazardous activities
due to possible blurred vision upon instillation, the drug should not be used to control a vehicle or operating machinery.

Product form
Eye drops 0.3%.
In 5 ml packaged in a plastic bottle with a dropper, closed screw cap with a guarantee-ring. 1 bottle with instruction on use is placed in a cardboard box.

Storage:
Store in a dark place at a temperature buy equipoise no higher than 25 ° C. Keep out of the reach of children.

Shelf life :
. 3 years
. Shelf life after opening the bottle – 4 weeks
Do not use after the expiration date printed on the package.

Conditions of supply
Prescription.

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